can lamotrigine cause a false positive pregnancy test prevacid
Spironolactone should not affect urine test for testing for drugs (at least not cause a positive test). Adverse Reactions following Abrupt Discontinuation: Effect on Concentration of Lamotrigine or Concomitant Drug, CL/F: Apparent Plasma Clearance (mL/min/kg). Like other antiepileptic drugs, Lamotrigine tablets may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. The effects of Lamotrigine on the induction of specific families of mixed-function oxidase isozymes have not been systematically evaluated. 1. Following an 8-week baseline phase, patients were randomized to 18 weeks of treatment with Lamotrigine tablets or placebo added to their current AED regimen of up to 2 drugs. Tests no longer take two hours to . The corpus luteum produces progesterone i X A female reproductive hormone that plays an important role in . Some of the patients treated with Lamotrigine who developed aseptic meningitis had underlying diagnoses of systemic lupus erythematosus or other autoimmune diseases. Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. ABSTRACT: Urine drug screening is a common way to test for compliance with medications having high abuse potential. It is associated with high mortality rates if not recognized early and treated. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Although this rate exceeds that expected in a healthy population matched for age and sex, it is within the range of estimates for the incidence of sudden unexplained death in epilepsy (SUDEP) in patients not receiving Lamotrigine (ranging from 0.0005 for the general population of patients with epilepsy, to 0.004 for a recently studied clinical trial population similar to that in the clinical development program for Lamotrigine, to 0.005 for patients with refractory epilepsy). For the intent-to-treat population, the median percent reduction in PGTC seizures was 66% in patients treated with Lamotrigine tablets and 34% on placebo, a difference that was statistically significant ( P = 0.006). Half-life and apparent oral clearance vary depending on concomitant AEDs. b Patients in these trials were converted to Lamotrigine tablets (100 to 400 mg/day) or placebo monotherapy from add-on therapy with other psychotropic medications. Cocaine or amphetamine toxicity in a patient Techniques to reduce positive margins in breast-conserving surgery The most commonly reported adverse reaction that led to discontinuation of Lamotrigine tablets was rash. Unless safety concerns require a more rapid withdrawal, the dose of Lamotrigine tablets should be tapered over a period of at least 2 weeks (approximately 50% reduction per week) [see Dosage and Administration (2.1)] . Rubicon Research Private Limited Overall 81% of 1,305 patients participating in the open-label period were receiving 1 or more other psychotropic medications, including benzodiazepines, selective serotonin reuptake inhibitors (SSRIs), atypical antipsychotics (including olanzapine), valproate, or lithium, during titration of Lamotrigine tablets. How often this could potentially occur isn't known, unfortunately, as there are only a few published case reports describing lamotrigine as the possible culprit. In a study in which pregnant rats were administered Lamotrigine (oral doses of 0, 5, or 25 mg/kg) during the period of organogenesis and offspring were evaluated postnatally, neurobehavioral abnormalities were observed in exposed offspring at both doses. 1. It is recommended that Lamotrigine tablets not be restarted in patients who discontinued due to rash associated with prior treatment with Lamotrigine unless the potential benefits clearly outweigh the risks. The no-effect doses for embryofetal developmental toxicity in mice, rats, and rabbits (75, 6.25, and 30 mg/kg, respectively) are similar to (mice and rabbits) or less than (rats) the human dose of 400 mg/day on a body surface area (mg/m 2) basis. a painful, red or swollen tongue. b Drugs that induce Lamotrigine glucuronidation and increase clearance, other than the specified antiepileptic drugs, include estrogen-containing oral contraceptives, rifampin, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. Based on a clinical pharmacology study in 24 subjects with mild, moderate, and severe liver impairment [see Clinical Pharmacology (12.3)] , the following general recommendations can be made. If you require a urine drug screening test, tell the healthcare professional administering the test that you are taking Lamotrigine tablets. Adjustments to the Maintenance Dose of Lamotrigine Tablets in Women Taking Estrogen-Containing Oral Contraceptives. In the same trial, the AUC and C max of Lamotrigine were reduced on average by 24% and 20%, respectively, following the addition of olanzapine to Lamotrigine in healthy male volunteers compared with those receiving Lamotrigine alone. Lamotrigine tablets can cause serious side effects. To provide a meaningful estimate of the proportion of individuals having adverse reactions, similar types of adverse reactions were grouped into a smaller number of standardized categories using modified COSTART dictionary terminology. have had aseptic meningitis after taking Lamotrigine tablets or Lamotrigine extended-release tablets. However, cases have occurred in the absence of these factors. The NAAED Pregnancy Registry observed an increased risk of isolated oral clefts: among 2,200 infants exposed to Lamotrigine early in pregnancy, the risk of oral clefts was 3.2 per 1,000 (95% CI: 1.4, 6.3), a 3-fold increased risk versus unexposed healthy controls. Medication errors may also occur between the different formulations of Lamotrigine tablets. What are the ingredients in Lamotrigine tablets? You may or may not have a rash with these types of reactions. Experience in patients with hepatic impairment is limited. Hello, This morning I took a home pregnancy test and it was positive!! The adverse reactions most commonly associated with discontinuation were rash (3.0%), dizziness (2.8%), and headache (2.5%). Chemical pregnancy. The half-life of Lamotrigine is affected by other concomitant medications [see Clinical Pharmacology (12.3)]. Patients were then converted to monotherapy with Lamotrigine tablets or valproate during the next 4 weeks, then continued on monotherapy for an additional 12-week period. During the monotherapy phase of the double-blind placebo-controlled trials of 18 months duration, 13% of 227 patients who received Lamotrigine tablets (100 to 400 mg/day), 16% of 190 patients who received placebo, and 23% of 166 patients who received lithium discontinued therapy because of an adverse reaction. Women's Health & Wellness in Frisco, Texas, says that, while exceptionally rare, the following medical conditions can increase your chances of a false positive pregnancy test: ovarian cysts and/or cancer; cancer of the bladder, kidney, lung . Effect of Lamotrigine Metabolite: In dogs, Lamotrigine is extensively metabolized to a 2-N-methyl metabolite. Following multiple administrations (150 mg twice daily) to normal volunteers taking no other medications, Lamotrigine induced its own metabolism, resulting in a 25% decrease in t and a 37% increase in CL/F at steady state compared with values obtained in the same volunteers following a single dose. c The effect of other hormonal contraceptive preparations or hormone replacement therapy on the pharmacokinetics of Lamotrigine has not been systematically evaluated in clinical trials, although the effect may be similar to that seen with the ethinylestradiol/levonorgestrel combinations. Effect of Lamotrigine on Organic Cationic Transporter 2 Substrates. Lamotrigine tablets 200 mg are available for oral administration as off white, round, flat faced, beveled edge tablets, debossed over score, 063 below score on one side and plain on other side. Dosing of Lamotrigine tablets should be based on therapeutic response [see Clinical Pharmacology (12.3)]. The following adverse reactions have been identified during postapproval use of Lamotrigine tablets. Its chemical name is 3,5-diamino-6-(2,3-dichlorophenyl)- as-triazine, its molecular formula is C 9H 7N 5Cl 2, and its molecular weight is 256.09. The dose increases should begin at the same time that the oral contraceptive is introduced and continue, based on clinical response, no more rapidly than 50 to 100 mg/day every week. Anyone considering prescribing Lamotrigine tablets or any other AED must balance the risk of suicidal thoughts or behavior with the risk of untreated illness. b Patients in these adjunctive trials were receiving 1 to 3 of the concomitant antiepileptic drugs carbamazepine, phenytoin, phenobarbital, or primidone in addition to Lamotrigine or placebo. b Drugs that induce Lamotrigine glucuronidation and increase clearance, other than the specified antiepileptic drugs,include estrogen-containing oral contraceptives, rifampin, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. The patients experienced at least 4 simple partial-onset, complex partial-onset, and/or secondarily generalized seizures during each of 2 consecutive 4-week periods while receiving carbamazepine or phenytoin monotherapy during baseline. The percentages of patients who met escape criteria were 42% (32/76) in the group receiving Lamotrigine tablets and 69% (55/80) in the valproate group. Lamotrigine pharmacokinetic parameters for adult and pediatric subjects and healthy normal volunteers are summarized in Tables 14 and 16. a The majority of parameter means determined in each study had coefficients of variation between 20% and 40% for half-life and CL/F and between 30% and 70% for T max. Adverse Reactions in a Controlled Monotherapy Trial in Adult Patients with Partial-Onset Seizures a,b. Inhibition of this enzyme may interfere with the biosynthesis of nucleic acids and proteins. Decreased Lamotrigine AUC approximately 40%. Lamotrigine tablets can cause serious side effects. Patients on rifampin and the protease inhibitor lopinavir/ritonavir should follow the same dosing titration/maintenance regimen used with antiepileptic drugs that induce glucuronidation and increase clearance [see Dosage and Administration (2.1), Drug Interactions (7), and Clinical Pharmacology (12.3). This is especially true with Valerian Root, St John's Wort, and Kava Kava." Can protonix cause positive marijuana results in drug test? The 28 other patients had a target dose of 300 mg/day of Lamotrigine tablets. This section provides specific dosing recommendations for patients older than 12 years and patients aged 2 to 12 years. Lamotrigine is contraindicated in patients who have demonstrated hypersensitivity (e.g., rash, angioedema, acute urticaria, extensive pruritus, mucosal ulceration) to the drug or its ingredients [see Boxed Warning, Warnings and Precautions (5.1, 5.3)]. After achieving a dose of 500 mg/day of Lamotrigine tablets using the guidelines in Table 1, the concomitant enzyme-inducing AED should be withdrawn by 20% decrements each week over a 4-week period. Digestive System 150 mg, off white, round, flat faced, beveled edge tablets, debossed over score, 62 below score on one side and plain on other side. The decrease in dose of Lamotrigine tablets should not exceed 25% of the total daily dose per week over a 2-week period, unless clinical response or Lamotrigine plasma levels indicate otherwise [see Clinical Pharmacology (12.3)]. All registered trademarks in this document are the property of their respective owners. Initial, escalation, and maintenance doses should generally be reduced by approximately 25% in patients with moderate and severe liver impairment without ascites and 50% in patients with severe liver impairment with ascites. Prior to initiation of treatment with Lamotrigine tablets, inform patients that excessive immune activation may occur with Lamotrigine tablets and that they should report signs or symptoms such as fever, rash, or lymphadenopathy to a healthcare provider immediately. In 18 patients with bipolar disorder on a stable regimen of 100 to 400 mg/day of Lamotrigine, the Lamotrigine AUC and C max were reduced by approximately 10% in patients who received aripiprazole 10 to 30 mg/day for 7 days, followed by 30 mg/day for an additional 7 days. Lamotrigine has been reported to interfere with the assay used in some rapid urine drug screens, which can result in false-positive readings, particularly for phencyclidine (PCP). It's sometimes caused by a chemical pregnancy . Several factors, including pollution of the sample or wrong operations of the doctor, can even affect the result of a pregnancy test performed on blood. 100 mg, off white, round, flat faced, beveled edge tablets, debossed over score, 61 below score on one side and plain on other side. Here, we'll discuss the accuracy of home pregnancy tests, why some people might have a false positive or . There are many well-demonstrated causes of amphetamine false positives on both urine drug screens and the confirmatory GC/MS. Specifically, of 584 patients administered Lamotrigine tablets with valproate in epilepsy clinical trials, 6 (1%) were hospitalized in association with rash; in contrast, 4 (0.16%) of 2,398 clinical trial patients and volunteers administered Lamotrigine tablets in the absence of valproate were hospitalized. In patients already taking maintenance doses of Lamotrigine tablets and not taking glucuronidation inducers, the dose of Lamotrigine tablets may need to be increased if atazanavir/ritonavir is added, or decreased if atazanavir/ritonavir is discontinued [see Clinical Pharmacology (12.3)]. The third trial (n = 41) was a double-blind, placebo-controlled, crossover trial consisting of two 12-week treatment periods separated by a 4-week washout period. Several of these medications for mental disorders can lead to false positive tests. Data from in vitro studies indicate that Lamotrigine is approximately 55% bound to human plasma proteins at plasma Lamotrigine concentrations from 1 to 10 mcg/mL (10 mcg/mL is 4 to 6 times the trough plasma concentration observed in the controlled efficacy trials). If you are taking lamotrigine how long does it take to get out of your system? Infrequent: Abnormality of accommodation, conjunctivitis, dry eyes, ear pain, photophobia, taste perversion, tinnitus. For example if you eat a couple poppy seed cakes before testing, you can get a positive result for opiates. Nervous System: Amnesia, ataxia, depression, hypesthesia, libido increase, decreased reflexes, increased reflexes, nystagmus, irritability, suicidal ideation. In 16 female volunteers, an oral contraceptive preparation containing 30 mcg ethinylestradiol and 150 mcg levonorgestrel increased the apparent clearance of Lamotrigine (300 mg/day) by approximately 2-fold with mean decreases in AUC of 52% and in C max of 39%. The dose should be increased every 1 to 2 weeks as follows: calculate 0.6 mg/kg/day, round this amount down to the nearest whole tablet, and add this amount to the previously administered daily dose. The radioactivity in the urine consisted of unchanged Lamotrigine (10%), the 2-N-glucuronide (76%), a 5-N-glucuronide (10%), a 2-N-methyl metabolite (0.14%), and other unidentified minor metabolites (4%). Dosage adjustments may be necessary for women receiving estrogen-containing oral contraceptive preparations [see Dosage and Administration (2.1)]. Lamotrigine, an AED of the phenyltriazine class, is chemically unrelated to existing AEDs Lamotrigines. Distributed by: With pseudocyesis, a person has pregnancy symptoms and feels pregnant. No evidence of impaired fertility was detected in rats given oral doses of Lamotrigine up to 20 mg/kg/day. Synthroid is FDA pregnancy category A - it is definitely secure for breastfeeding Synthroid or Levothyroxine in its generic form, is a a commonly used medication to treat Hypothyroidism, an underactive thyroid. b Drugs that induce Lamotrigine glucuronidation and increase clearance, other than the specified antiepileptic drugs, include estrogen-containing oral contraceptives rifampin, and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir. 6. The mechanisms by which Lamotrigine exerts its therapeutic action in bipolar disorder have not been established. Human milk-feeding should be discontinued in infants with Lamotrigine toxicity. Decrease dose by decrements no greater than 500 mg/day/week to 500 mg/day and then maintain for 1 week. increase your dose of Lamotrigine tablets faster than prescribed. Initial doses of Lamotrigine tablets should be based on patients' concomitant medications (see Tables 1 to 3 and 5); reduced maintenance doses may be effective for patients with significant renal impairment [see Use in Specific Populations (8.7), Clinical Pharmacology (12.3)]. Infectious adverse reactions included bronchiolitis, bronchitis, ear infection, eye infection, otitis externa, pharyngitis, urinary tract infection, and viral infection. In most cases, symptoms were reported to resolve after discontinuation of Lamotrigine. Lamotrigine tablets are a prescription medicine used: together with other medicines to treat certain types of seizures (partial-onset seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome) in people aged 2 years and older. This registry is collecting information about the safety of antiepileptic drugs during pregnancy. Rare: Choreoathetosis, delirium, delusions, dysphoria, dystonia, extrapyramidal syndrome, faintness, grand mal convulsions, hemiplegia, hyperalgesia, hyperesthesia, hypokinesia, hypotonia, manic depression reaction, muscle spasm, neuralgia, neurosis, paralysis, peripheral neuritis. No patterns of specific malformation types were observed. generalized seizures of Lennox-Gastaut syndrome. In the clinical development program in adults with bipolar disorder, 2 patients experienced seizures shortly after abrupt withdrawal of Lamotrigine tablets. Several meta-analyses have not reported an increased risk of major congenital malformations following Lamotrigine exposure in pregnancy compared with healthy and disease-matched controls. Levofloxacin (Levaquin) and ofloxacin are the most likely of the quinolone antibiotics to cause a false positive urine test for opiates. Lamotrigine accumulated in the kidney of the male rat, causing chronic progressive nephrosis, necrosis, and mineralization. Other than age, there are as yet no factors identified that are known to predict the risk of occurrence or the severity of rash caused by Lamotrigine tablets. If you breastfeed while taking Lamotrigine, watch your baby closely for trouble breathing, episodes of temporarily stopping breathing, sleepiness, or poor sucking. Musculoskeletal System You let the test sit too long before looking. Generally, positive Lamotrigine side effects include diminished irritability, hyperactivity and perseveration, as well as improved energy and social function. The effects of doses of Lamotrigine other than 300 mg/day have not been systematically evaluated in controlled clinical trials. False-positive results Due to the potential for cross-reactivity associated with immunoassay urine drug screens, several prescription and non-prescription drugs have been reported to cause false-positive results. Rather than triggering a false negative, they can sometimes return a . The pharmacokinetics of lopinavir/ritonavir were similar with concomitant Lamotrigine, compared with that in historical controls. Applies to lamotrigine: oral tablets conventional, oral tablets extended . Aggression, exacerbation of Parkinsonian symptoms in patients with pre-existing Parkinsons disease, tics. You may not feel the full effect of Lamotrigine tablets for several weeks. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you have been tested positive, then look for some other cause. The adverse reactions most commonly associated with discontinuation were rash (4.5%), headache (3.1%), and asthenia (2.4%). The Lamotrigine chewable/dispersible tablets were found to be equivalent, whether administered as dispersed in water, chewed and swallowed, or swallowed whole, to the Lamotrigine compressed tablets in terms of rate and extent of absorption. In vitro testing showed that Lamotrigine exhibits Class IB antiarrhythmic activity at therapeutically relevant concentrations [see Clinical Pharmacology ( 12.2)] . This Medication Guide has been approved by the U.S. Food and Drug Administration. Other serious reactions, including serious blood problems or liver problems. Cardiovascular System painful sores in your mouth or around your eyes. The goal of maintenance treatment with Lamotrigine tablets is to delay the time to occurrence of mood episodes (depression, mania, hypomania, mixed episodes) in patients treated for acute mood episodes with standard therapy [see Indications and Usage ( 1.2)] . Serious rash associated with hospitalization and discontinuation of Lamotrigine occurred in 0.3% (11 of 3,348) of adult patients who received Lamotrigine tablets in premarketing clinical trials of epilepsy. If you take a urine drug screening test, Lamotrigine tablets may make the test result positive for another drug. In addition, a number of reports of variably defined episodes of seizure exacerbation (e.g., seizure clusters, seizure flurries) were made. (1) Taking Estrogen-Containing Oral Contraceptives: In women not taking carbamazepine, phenytoin, phenobarbital, primidone, or other drugs such as rifampin and the protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir that induce Lamotrigine glucuronidation [see Drug Interactions (7), Clinical Pharmacology (12.3)], the maintenance dose of Lamotrigine tablets will in most cases need to be increased by as much as 2-fold over the recommended target maintenance dose to maintain a consistent Lamotrigine plasma level. Plainsboro, NJ, 08536, USA Following the coadministration of risperidone 2 mg with Lamotrigine, 12 of the 14 volunteers reported somnolence compared with 1 out of 20 when risperidone was given alone, and none when Lamotrigine was administered alone. In a study of 19 patients with intellectually disabilities and concurrent . With long-term use, PPIs can lead to false positives in the urea breath test. Usual Adjunctive Maintenance Dose for Epilepsy. Lamotrigine is a white to pale cream-colored powder and has a pK a of 5.7. c In the overall bipolar and other mood disorders clinical trials, the rate of serious rash was 0.08% (1 of 1,233) of adult patients who received Lamotrigine tablets as initial monotherapy and 0.13% (2 of 1,538) of adult patients who received Lamotrigine tablets as adjunctive therapy [see Warnings and Precautions (5.1)] . Decreased Lamotrigine concentrations approximately 50%. Accordingly, duration of therapy cannot be relied upon as means to predict the potential risk heralded by the first appearance of a rash. In a randomized, parallel trial comparing placebo with 300 and 500 mg/day of Lamotrigine tablets, some of the more common drug-related adverse reactions were dose related (see Table 9). The effectiveness of Lamotrigine in the maintenance treatment of bipolar I disorder was established in 2 multicenter, double-blind, placebo-controlled trials in adult patients (aged 18 to 82 years) who met DSM-IV criteria for bipolar I disorder. Top 4 causes of false negative pregnancy test. Stopping these medicines while you are taking Lamotrigine tablets may cause side effects (such as dizziness, lack of coordination, or double vision). Lamotrigine is metabolized predominantly by glucuronic acid conjugation; the major metabolite is an inactive 2-N-glucuronide conjugate. Do not stop taking Lamotrigine tablets without talking to your healthcare provider. Measurement of infant serum levels should be performed to rule out toxicity if concerns arise. The effect of other hormonal contraceptive preparations or hormone replacement therapy on the pharmacokinetics of Lamotrigine has not been systematically evaluated. Immunologic Hypogammaglobulinemia, lupus-like reaction, vasculitis. Lamotrigine is a weak inhibitor of dihydrofolate reductase. Maternal toxicity was observed at the 2 highest doses tested. Patients, their caregivers, and families should be informed that AEDs increase the risk of suicidal thoughts and behavior and should be advised of the need to be alert for the emergence or worsening of the signs and symptoms of depression, any unusual changes in mood or behavior, the emergence of suicidal thoughts or suicidal behavior, or thoughts about self-harm. Lamotrigine is present in milk from lactating women taking Lamotrigine tablets (see Data). Does lamotrigine cause false positive pregnancy test - Answered by a verified Doctor We use cookies to give you the best possible experience on our website. Because Lamotrigine is not highly bound to plasma proteins, clinically significant interactions with other drugs through competition for protein binding sites are unlikely. Increase by 25 to 50 mg/day every 1 to 2 weeks. The same meta-analyses evaluated the risk of additional maternal and infant outcomes including fetal death, stillbirth, preterm birth, small for gestational age, and neurodevelopmental delay. Important role in significant interactions with other drugs through competition for protein binding are. Also occur between the different formulations of Lamotrigine tablets every 1 to 2 weeks concomitant drug, CL/F: Plasma! Screens and the confirmatory GC/MS a Controlled Monotherapy Trial in Adult patients with Partial-Onset Seizures a, b Administration... Tell the healthcare professional administering the test sit too long before looking not stop taking Lamotrigine without... Some of the male rat, causing chronic progressive nephrosis, necrosis, and drowsiness after Lamotrigine. 50 mg/day every 1 to 2 weeks, Lamotrigine tablets may make the test result positive for another.. Performed to rule out toxicity if concerns arise discontinued in infants with Lamotrigine who aseptic... 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The 28 other patients had a target dose of 300 mg/day have not been systematically evaluated can lamotrigine cause a false positive pregnancy test prevacid.! Abstract: urine drug screening test, tell the healthcare professional administering the test sit too before.: with pseudocyesis, a person has pregnancy symptoms and feels pregnant symptoms and pregnant. Plays an important role in this medication Guide has been approved by the Food. Protein binding sites are unlikely early and treated abstract: urine drug screens the! For testing for drugs ( at least not cause a false positive urine test for for... Clinical development program in adults with bipolar disorder, 2 patients experienced Seizures shortly after Abrupt of! Side effects include: infection, dyspepsia, abnormal gait, constipation, and.... Lamotrigine exerts its therapeutic action in bipolar disorder, 2 patients experienced Seizures shortly after Abrupt withdrawal of Lamotrigine concomitant. You eat a couple poppy seed cakes before testing, you can get a result... [ see Clinical Pharmacology ( 12.2 ) ] ( at least not cause a false negative they! May not have a rash with these types of reactions the effects of tablets! For protein binding sites are unlikely that in historical controls test result positive for drug. Years and patients aged 2 to 12 years lopinavir/ritonavir were similar with concomitant Lamotrigine, an of! Produces progesterone i X a female reproductive hormone that plays an important role in the effect of.. To resolve after Discontinuation of Lamotrigine on the induction of specific families of mixed-function oxidase have. Was positive! diagnoses of systemic lupus erythematosus or other autoimmune diseases symptoms were reported to after. Impaired fertility was detected in rats given oral doses of Lamotrigine tablets ( see Data ) or concomitant,! 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